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INTRODUCTION AND METHODS

The stereo electron micrographs presented on this page are all obtained from the brain cortex of a 25 month old, "demented" transgenic mouse produced by Dr. Karen K. Hsiao of the University of Minnesota in Minneapolis, coded animal #1562 in her laboratory records. (Because the APP gene of the Swedish form of familial Alzheimer's disease was introduced into this mouse, it will henceforth be called the "Alzheimer's mouse".) Its brain was perfused with glutaraldehyde in a physiological buffer and vibrotome-sectioned before quick-freezing. Then the frozen sections were freeze-fractured, rotary-replicated with platinum, and photographed at in a transmission electron microscope at approx. 50,000X magnification.

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Heuser Lab
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