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Still Images | QuickTime Movies
Still Image Galleries
Alzheimer's Amyloids
The stereo electron micrographs presented on this page are all obtained from the brain cortex of a 25 month old, "demented" transgenic mouse produced by Dr. Karen K. Hsiao of the University of Minnesota in Minneapolis, coded animal #1562 in her laboratory records. (Because the APP gene of the Swedish form of familial Alzheimer's disease was introduced into this mouse, it will henceforth be called the "Alzheimer's mouse".) Its brain was perfused with glutaraldehyde in a physiological buffer and vibrotome-sectioned before quick-freezing. Then the frozen sections were freeze-fractured, rotary-replicated with platinum, and photographed at in a transmission electron microscope at approx. 50,000X magnification.
 
Classics

Here, you can view many of our classic electron micrographs, ranging all the way from 1980 to the present day. The introductory page to this gallery contains an index to the different categories it contains, allowing you to either browse through all categories in sequence or begin your tour in a specific location within the collection.

Actin+S1, Axostyles, Basal Laminae, Brush Borders, Clathrin Cages, Coated Pits (new), Coated Pits (old), Coated Vesicles, Crystals, FS Cells, Liposomes, Motors, Muscle, Neuromuscular Junction: New Thin Section, Neuromuscular Junction: Old Thin Section, Neuromuscular Junction: Freeze Fracture, Neuromuscular Junction: Deep Etch, Rec A, Synapse, Torpedo Electric Organ, Styryl Dyes, Phagocytosis, Axonemes, Caveolae

 
Dicty Contractile Vacuoles
Contractile vacuoles are cavities within cells that fill with water and then contract, expelling their contents into the cell, thus performing osmoregulation and excretion functions.
 
Endoplasmic Reticulum
Endoplasmic reticulum is made up of networks of membrane-bound tubules that are located in the cytoplasm of the cell. There are two types; rough ER, which is where ribosomes are found, is involved in protein synthesis. Smooth ER is involved in cellular synthesis. Endoplasmic reticulum can also serve to transport substances from point to point within the cell.
 
NSF
NSF, also known as NEM-Sensitive Membrane Fusion Factor, facilitates trafficking events (cytoplasmic membrane fusion) since it is involved in the process of "docking" to the target membrane.
 
VacA
VacA is an abbreviated term for "Helicobacter pylori vacuolating cytotoxin". It is an important part of H. pylori's virulence factors (the organism is what causes chronic superficial gastritis, peptic ulcers, and gastrous carcinoma.) VacA is an important part of the process by which this organism infects its hosts.
 
QuickTime Movies
Borellia Phago
QuickTime, 2,971K
Dicty (Snacking)
QuickTime, 628K
Listeria Rocketing
QuickTime, 2,811K
Listeria Uptake
QuickTime, 1,981K
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This includes all micrographs!

Campus Box 8228
660 S. Euclid Ave.
St. Louis, Mo. 63110
Heuser Lab
4566 Scott Ave. Dept. 8228
St. Louis, Mo. 63110