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Alzheimer's
Amyloids |
| The stereo electron
micrographs presented on this page are all obtained
from the brain cortex of a 25 month old, "demented" transgenic
mouse produced by Dr. Karen K. Hsiao of the
University of Minnesota in Minneapolis, coded
animal #1562 in her laboratory records. (Because
the APP gene of the Swedish form of familial
Alzheimer's disease was introduced into this
mouse, it will henceforth be called the "Alzheimer's
mouse".) Its brain was perfused with glutaraldehyde
in a physiological buffer and vibrotome-sectioned
before quick-freezing. Then the frozen sections
were freeze-fractured, rotary-replicated with
platinum, and photographed at in a transmission
electron microscope at approx. 50,000X magnification. |
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Classics |
Here, you can
view many of our classic electron micrographs,
ranging all the way from 1980 to the present
day. The introductory page to this gallery
contains an index to the different categories
it contains, allowing you to either browse
through all categories in sequence or begin
your tour in a specific location within the
collection.
Actin+S1, Axostyles, Basal
Laminae, Brush
Borders, Clathrin
Cages, Coated
Pits (new), Coated
Pits (old), Coated
Vesicles, Crystals, FS
Cells, Liposomes, Motors, Muscle, Neuromuscular
Junction: New Thin Section, Neuromuscular
Junction: Old Thin Section, Neuromuscular
Junction: Freeze Fracture, Neuromuscular
Junction: Deep Etch, Rec
A, Synapse, Torpedo
Electric Organ, Styryl
Dyes, Phagocytosis, Axonemes, Caveolae |
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Dicty
Contractile Vacuoles |
| Contractile vacuoles
are cavities within cells that fill with water
and then contract, expelling their contents
into the cell, thus performing osmoregulation
and excretion functions. |
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Endoplasmic
Reticulum |
| Endoplasmic reticulum
is made up of networks of membrane-bound tubules
that are located in the cytoplasm of the cell.
There are two types; rough ER, which is where
ribosomes are found, is involved in protein
synthesis. Smooth ER is involved in cellular
synthesis. Endoplasmic reticulum can also serve
to transport substances from point to point
within the cell. |
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NSF |
| NSF, also known as
NEM-Sensitive Membrane Fusion Factor, facilitates
trafficking events (cytoplasmic membrane fusion)
since it is involved in the process of "docking" to
the target membrane. |
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VacA |
| VacA is an abbreviated
term for "Helicobacter pylori vacuolating
cytotoxin". It is an important part of H.
pylori's virulence factors (the organism
is what causes chronic superficial gastritis,
peptic ulcers, and gastrous carcinoma.) VacA
is an important part of the process by which
this organism infects its hosts. |
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