Tanya Tenkova, M.D.
NAME Tatyana Ilieva Tenkova-Heuser
BORN March 27, 1950, Varna, Bulgaria
CITIZENSHIP United States (since 2002)
PERSONAL Married with 1 daughter, 1 stepdaughter, and 2 stepsons
EDUCATION
  • Secondary School (Graduated 1969) Christo Kabakchiev English School, Varna, Bulgaria
  • College & Graduate School (M.D.Degree 1979) Varna Institute of Medicine; Varna, Bulgaria
  • Postgraduate Specialty Certification (1986) Specialist in Anatomy and Histology; Varna Institute of Medicine; Varna, Bulgaria
PRESENT POSITION

Research Assistant in Neurobiology and Psychiatry
Washington University School of Medicine
660 South Euclid Avenue, St. Louis, Missouri 63110

EXPERIENCE
1979-1980 Fellow in Cardiology Clinic
Varna Medical University, Varna, Bulgaria
1981-1982 Fellow in Endocrinology Clinic
Varna Medical University, Varna, Bulgaria
1983-1990 Assistant Professor in Anatomy & Histology
Varna Medical University, Varna, Bulgaria
1991

Visiting scientist, Department of Ophthalmology
Yamanashi Medical University, Yamanashi, Japan

Laboratory Animal Center
Ehime University School of Medicine
Shigemobu Ehime, Japan

1992-1994 Research Assistant in Ophthalmology
Washington University School of Medicine, St. Louis, MO
1995-present Research Assistant in Neurobiology & Psychiatry
Washington University School of Medicine, St. Louis, MO
1998 Visiting scientist, Pediatric Neurology
Charity-Virchow Clinics
Humboldt University, Berlin, Germany
1999-present Faculty of Medical School Histology Course
Washington University School of Medicine, St. Louis, MO
PROFESSIONAL ACTIVITIES

European Cytoskeletal Club
European Association for Eye Research
Bulgarian Union of Scientists
Bulgarian Society of Anatomists and Histologists
Bulgarian Eye Research Society
Society for Neuroscience

Papers

  1. Tenkova, T., and G. Chaldakov. (1988) Golgi-cilium complex in rabbit ciliary process cells. Cell Struct Funct 13: 455-458.
  2. Tenkova, T., and G. Chaldakov. (1989) The internalized gap junctions in rabbit ciliary epithelium. A TEM study.  Vehr Anat Ges 82, Anat Anzeiger Suppl 164: 961-978.
  3. Tenkova, T., and G. Chaldakov. (1990) Internalized gap junctions in ciliary epithelium of rabbit and rat. Cell Tissue Res 261: 205-210.
  4. Tenkova, T., Kardalev, S., and G. Chaldakov. (1991) cAMP phosphodiesterase inhibitors in ciliary process epithelium; Ultrastructural mitochondrial alterations. Doc Ophthal 77: 2-13.
  5. Nobukasu, A., Tenkova, T., Fujiwara, T., and Y. Takashima. (1993) The shape and distribution of lysosomes and endocytosis in ciliary epithelial cells of rats. Cell Tissue Res 274: 65-70.
  6. Tenkova, T., Kondo, M., Fujiwara, T., and S.H. Tsukahara. (1993) Sympathetic hyperinnervation protects vascular smooth muscle cells from necrosis in stroke prone spontaneously hypertensive rats. Virchows Arch B Cell Pathol 64: 373-377.
  7. Kondo, M., Tenkova, T., and T. Fujiwara. (1996) Dual effect of sympathetic hyperfunction on blood vessels in spontaneously hypertensive rats. Biomed Rev 6: 57-58.
  8. Wax, M., Saito, I., Tenkova, T., Krupin, T., Becker, B., Nelson, N., Brown, D., and S. Gluck. (1997) Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci USA 94: 6752-6757.
  9. Corso, T.D., Sesma, M.A., Tenkova, T.I., Der, T.C., Wozniak, D.E., Farber, N.B., and J.W. Olney. (1997) Multifocal brain damage induced by phencyclidine is augmented by pilocarpine. Brain Res 752: 1-14.
  10. Mosinger-Ogilvie, J., Tenkova, T., Lett, J.M., Speck, J., Landgraf, M., and M.S. Silverman. (1997) Age related distribution of cones and ON-bipolar cells in the rd mouse retina. Current Eye Res 16: 244-251.
  11. Mohand-Sid, S., Hick, D., Simonutti, M., Tran-Minhj, D., Deudon-Combe, A., Drefus, H., Sahel, J., Silverman, M.S., Mosinger-Ogilvie, J., and T. Tenkova. (1997) Photoreceptor transplants increase host cone survival in the retinal degeneration (rd) mouse. Ophthalmic Res 29: 290-297.
  12. Corso, T.D., Sesma, M.A., Tenkova, T.I., Der, T.C., Wozniak, D.F., Farber, N.B., and J.W. Olney. (1997) Multifocal brain damage induced by phencyclidine is augmented by pilocarpine. Brain Res 752: 1-14.
  13. Dikranian, K., Stoinov, N., and T. Tenkova. (1997) Effect of leucotriene E4 on the microvascular endothelium: an ultrastructural study. Acta Morphol Anthropol
  14. Wozniak, D.F., Dikranian, K., Ishimaru, M.J., Nardi, A., Corso, T.D., Tenkova, T., Olney, J.W., and A.S. Fix. (1998) Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer’s disease. Neurobiol Dis 5: 305-322.
  15. Fujiwara, T,. Tenkova, T.I., and M. Kondo. (1999) Wall cytoarchitecture of the rat ciliary process microvasculature revealed with scanning electron microscopy. Anat Rec 254: 261-268.
  16. Ishimaru, M.J., Ikonomidou, C., Tenkova, T.I. Der, T.C., Dikranian, K., Sesma, M.A., and J.W. Olney. (1999) Distinguishing excitotoxic from apoptotic neurodegeneration in the developing rat brain. J Comp Neurol 408: 461-476.
  17. Chen, Q., Moulder, K., Tenkova, T., Hardy, K., Olney, J.W., and C. Romano. (1999) Excitotoxic cell death dependent on inhibitory receptor activation. Exp Neurol 160: 215-225.
  18. Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T., Stevoska, V., Turski, L. and J.W. Olney. (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283: 70-74
  19. Ikonomidou, C., Bittigau, P., Ishimaru, M.J., Wozniak, D.F., Koch, C., Genz, K., Price, M.T., Stefovska, V., Hörster, F., Tenkova, T., Dikranian, K. and J.W. Olney. (2000) Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 287: 1056-1060.
  20. Ikonomidou, C., Bittigau, P., Ishimaru, M.J., Wozniak, D.F., Koch, C., Genz, K., Price, M.T., Stefovska, V., Hörster, F., Tenkova, T., Dikranian, K. and J.W. Olney. (2000) Induced damage in the developing brain. Science 288: 976-977.
  21. Holtzman, D.M., Bales, K.R., Tenkova, T.I,. Fagan, A.M., Parsadanian, M., Sartorius, .LJ., Mackey, B., Olney, J.W., McKeel, D.W., Wozniak, D.F. and S.M. Paul . (2000) Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease. Proc Nat Acad Sci 97: 2892-2897.
  22. Holtzman, D.M., Fagan, A.M., Mackey, B., Tenkova, T., Sartorius, L., Paul, S.M., Bales, K., Ashe, K.H., Irizarry, M.C. and B.T. Hyman. (2000) Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 47: 739-747.
  23. Ikonomidou, C., Bittigau, P., Koch, C,. Genz, K., Hoerster, F., Felderhoff-Mueser, U., Tenkova, T., Dikranian, K. and J. Olney. (2001) Neurotransmitters and apoptosis in the developing brain. Biochem Pharmacol 62: 401-405.
  24. Dikranian, K., Ishimaru, M.J., Tenkova, T., Labruyere, J., Qin, Y.Q., Ikonomidou, C. and J.W. Olney. (2001) Apoptosis in the in vivo mammalian forebrain. Neurobiol Dis 8: 359-379.
  25. Olney, J.W., Tenkova, T., Dikranian, K., Labruyere, J., Qin, Q.Y., and C Ikonomidou. (2002) Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Dev Brain Res 133: 115-126.
  26. Olney, J.W., Tenkova, T., Dikranian, K., Muglia, L.J., Jermakowicz, W.J., D’Sa, C. and K.A. Roth. (2002) Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis 9: 205-219.
  27. Young, C., Klocke, B., Tenkova, T., Choi, J., Labruyere, J., Qin, Q., Holtzman, D., Roth, K. and J.W. Olney. (2003) Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Diff 10: 1148-1155.
  28. Tenkova, T., Young, C., Dikranian, K., Labruyere, J., and J.W. Olney. (2003) Ethanol-Induced Apoptosis in the developing visual system during synaptogenesis. Invest Ophth Vis Sci 44: 2809-2817.
  29. Young C, Tenkova T, Dikranian K, Olney J. (2004) Excitotoxicversus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia. Review Curr Mol Med. 4(2):77-85.
  30. Wozniak DF, Hartmen RE, Boyle MP, Vogt SK, Brooks AR, Tenkova T, Young C, Olney JW, Muglia LJ. (2004) Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficit in juveniles followed by progressive functional recovery in adults. Neurobiol Dis. 17 (3):403-14.
  31. Young C, Jevtovic – Todorovic V, Quin YO, Tenkova T, Wang H, Labruyere J, Olney JW. (2005). Potential of ketamine and midozolam, individually or combination, to induce apoptotic neurodegeneration in the infant mouse brain . Br. J. Pharamacology  Jul4 (Epub ahead of print ).
  32. Mario Valentino, Tatyana Tenkova, Ping Yan, Isao Inoule, Kevin Yamada, Mark Goldberg. Delayed axonal degeneration after glucose deprivation is attenuated by AMPA/kainate receptor blockade. Neuroscience ( in press ).
  33. Mario Valentino, Tatyana Tenkova, Marie Kozel, Mark Goldberg.  Oligodendrocyte  injury after transient oxygen glucose deprivation.  Stroke (MS in preparation)

Abstracts

  1. Tenkova, T., Mitov, T., and S. Kardalev. (1987) Boven’s tumor (carcinoma in cito) treated by layered keratoplasty. Actual Problems of Ophthalmology Varna, Bulgaria.
  2. Tenkova, T. (1987) Electron microscopic study of ciliary body stroma in the eye with the second glaucoma. Actual Problems of Ophthalmology Varna, Bulgaria.
  3. Mitov, T., Kardalev, S., and T. Tenkova. (1987) Morphological changes in cornea after intralamelar implantation of the posterior lens capsule at bullate keratophathy. Actual Problems of Ophthalmology, Varna, Bulgaria.
  4. Tenkova,T., and G. Chaldakov. (1988) Golgi cilium complex and cell secretion. European Symposium on the Structure and Function of the Cytoskeleton, Lyon, France.
  5. Andonov, M., Dikranyan, K., Tenkova, T., and G. Chaldakov. (1988) Pyroantimonate method in different tissues by transmission electron microscopy. Third Symposium and School of Histochemistry and Cytochemistry, Varna, Bulgaria.
  6. Tenkova, T., and G. Chaldakov. (1988) Microtubules in ciliary process epithelium. Assoc. for Eye Research 29th Meeting, Albena, Bulgaria.
  7. Tenkova, T., Kardalev, S., and G. Chaldakov. (1988) Gap junctions in rabbit ciliary epithelium. Assoc. for Eye Research 29th Meeting, Albena, Bulgaria.
  8. Tenkova, T., Kardalev, S., Watanabe, H., and G. Chaldakov. (1989) EM and freeze fracture study of gap junctions in rat and rabbit ciliary process epithelium. Balkan Congress on Electron Microscopy, Athens, Greece.
  9. Tenkova, T., and S. Kardalev. (1990) Ciliary epithelium as proton secreting cells. TEM evidence. Ophthalmology 4.
  10. Tenkova, T., and G. Chaldakov. (1990) Morphological features of proton secreting cells in ciliary process epithelium. 9th International Congress of Eye Research, Helsinki, Finland.
  11. Tenkova, T., Kardalev, S., and G. Chaldakov. (1990) Ultrastructure of ciliary process and production of aqueous humor. Twenty-first Semaine Medical Balcanique, Varna, Bulgaria.
  12. Tenkova, T., Petrov, M., Fujiwara, T., and S.H. Tsukahara. (1992) Pericytes of ciliary process capillaries in rats. SEM study. Stressa, Italy.
  13. Tenkova, T., Dykranyan, K., Petrov, M., Yamabayashy, SH., and S.H. Tsukahara. (1992) Ultrastructure of ciliary processes, studied by cationic probes, freeze-fracture and deep-etching, EUREM 92, Grenada, Spain.
  14. Mosinger-Ogilvie, J., Landgraf, M., Lett, J.M., Tenkova, T., Wang, X., Wu, M., and M.S. Silverman. (1994) Synaptic connectivity of transplanted photoreceptors in rd mice expressing the transgenic marker gene LAcZ. ARVO Meeting, Sarasota, Florida.
  15. Wax, M.B., Barret, D.A., Tenkova, T., Becker, B., and S.L. Gluck. (1994) Plasma membrane localization of vacuolar H+ ATPase in ocular ciliary epithelium. ARVO Meeting, Sarasota, Florida.
  16. Corso, T.D., Der, T.C., Tenkova, T.I., Labruyere, J., Wozniak, D.F., and J.W. Olney. (1995) Disseminated neuronal necrosis induced by phencyclidine (PCP) in rat brain. Effect of co-treatment with pilocarpine. Soc Neurosci Abst 21: 351.
  17. Ishimaru, M., Der, T.C., Tenkova, T.I., Sesma, M.A., Thurston, J.H., and J.W. Olney. (1995) Three types of excitotoxicity evaluated for “apoptosis” signals. Soc Neurosci Abst 21: 1584.
  18. Dikranian, K., Ishimaru, M.J., Tenkova, T., Ikonomidou, C., and J.W. Olney. (1998) Histological characterization of apoptotic neurodegeneration induced in the developing rat CNS by NMDA antagonists. Soc Neurosci Abst 24: 1299.
  19. Price, M.T., Wozniak, D.F., Tenkova, T., Dikranian, K., Ikonomidou, C., and J.W. Olney. (1999) Ethanol induces widespread apoptotic neurodegeneration in the fetal guinea pig brain. Soc Neurosci Abst 25: 550.
  20. Olney, J.W., Wozniak, D.F., Price, M.T., Tenkova, T., Dikranian, K., and C. Ikonomidou. (1999) Ethanol induces widespread apoptotic neurodegeneration in the infant mouse brain. Soc Neurosci Abst 25: 550.
  21. Bittigau, P., Genz, K., Bosch-Hörster, F., Vöckler, J., Dikranian, K., Tenkova, T., Olney, J.W., and C. Ikonomidou. (1999) Barbiturates and benzodiazepines cause apoptotic neurodegeneration in the developing rat brain. Soc Neurosci Abst 25: 551.
  22. Dikranian, K., Tenkova, T., Ikonomidou, C., and J.W. Olney. (1999) Histological characterization of apoptotic neurodegeneration induced in the developing rodent brain by barbiturates and benzodiazepines. Soc Neurosci Abst 25: 1777.
  23. Holtzman, D.M., Tenkova, T.I., Bales, K.R., Paul, S.M, Olney, J.W., McKeel, D.W. and D.F. Wozniak. (1999) Marked neuritic degeneration is apolipoprotein E-dependent in the APPV717F mouse model of Alzheimer’s Disease. Soc Neurosci Abst 25: 1058.
  24. Dikranian, K., Tenkova, T., Bittigau, P., Ikonomidou, C. and J.W. Olney. (2000) Histological characterization of apoptotic neurodegeneration induced in the developing rat brain by drugs that block sodium channels. Soc Neurosci Abst 26: 323.
  25. Tenkova, T., Price, M.T., Labruyere, J. and J.W. Olney. (2000) Drug-induced apoptosis in the visual system during synaptogenesis. Soc Neurosci Abst 26: 71.
  26. Price, M.T., Tenkova, T., Cai, W.H. and J.W. Olney (2000). Ethanol-induced apoptosis in the visual system during synaptogenesis . Soc Neurosci Abst 26: 324.
  27. Price, M.T., Tenkova, T. and J.W. Olney. (2001) Caspase-3 activation accompanies apoptotic but not excitotoxic neurodegeneration in the developing mouse retina and brain. Soc Neurosci Abs 27: 450, 2001.
  28. Tenkova, T., Muglia, L., Dikranian, K., Roth, K. and J.W. Olney. (2001) Ethanol triggers a widespread pattern of caspase-3 activation and an identical pattern of apoptotic neurodegeneration in the developing mouse brain. Soc Neurosci Abs 27: 450.
  29. Olney, J.W., Tenkova, T., Holtzman, D. and K. Roth. (2001) Ethanol triggers widespread caspase-3 activation and apoptotic neurodegeneration in wild type but not Bax-deficient mice. Soc Neurosci Abs 27: 337.
  30. Wozniak, D.F., Hartman, R., Pieper, A., Vogt, S.K., Tenkova, T., Olney, J.W. and L.J. Muglia. Neonatal ethanol treatment induces apoptotic neurodegeneration and learning/memory deficits in mice. (2002) Program No. 207.12. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. CD-ROM.
  31. Olney, J.W., Tenkova, T., Ikonomidou, C. and C. Young. (2002) Threshold Conditions for Triggering Alcohol-Induced Apoptotic Neurodegeneration in Infant Mouse Brain. Program No. 120.1. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience. CD-ROM.
  32. Young, C., Tenkova, T., Wang, H., Qin, Y., Labruyere, J., Jevtovic-Todorovic, V., and J.W. Olney. (2003). A single sedating dose of ketamine causes neuronal apoptosis in the developing mouse brain. Soc Neurosci Abs 748.6.
  33. Young, C., B. J. Klocke, T. Tenkova, J. Choi, J. Labruyere, Y. Q. Qin, D. M. Holtzman, K. A. Roth and J. W. Olney (2003). Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ 10: 1148-55.
  34. Tenkova, T., C. Young, K. Dikranian, J. Labruyere and J. W. Olney (2003). Ethanol-induced apoptosis in the developing visual system during synaptogenesis. Invest Ophthalmol Vis Sci 44: 2809-17.
  35. Wozniak, D. F., R. E. Hartman, M. P. Boyle, S. K. Vogt, A. R. Brooks, T. Tenkova, C. Young, J. W. Olney and L. J. Muglia (2004). Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis 17: 403-14.
  36. Young, C., T. Tenkova, K. Dikranian and J. W. Olney (2004). Excitotoxic versus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia. Curr Mol Med 4: 77-85.
  37. M.Valentino, T.Tenkova, W.B.Macklin, M.P. Goldberg. (2005). Visualization of hypoxic oligodendrocyte injury in PLP-EGFP transgenic mice. Soc Neurosci Abs.
  38. Young, C., V. Jevtovic-Todorovic, et al. (2005). Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain." Br J Pharmacol 146: 189-97.
  39. Tenkova, T.I. and Goldberg, M.P. (2007). "A modified silver technique (De Olmos stain) for assessment of neuronal and axonal degeneration." In: Neuroprotection Methods and Protcols. Cliffton: Humana Press.